Which Antidepressant Is Right for Me?

A young african american girl sitting on her bed with a sad look holding her antidepressants

Deciding to explore antidepressant medication is a significant step in your mental health journey. Whether you are new to the idea of antidepressants or have considered them before, it is natural to have questions about which medication might be the best fit for you. In today’s guide, we will explore several different types of antidepressants, their common brand names, and factors to consider when discussing your options with your healthcare provider.

Talk to your Geode provider about your antidepressant options

Before we dive into the details, remember that this article is meant to provide a general overview of common options used to treat major depressive disorder. Your Geode mental health care provider is your best source of advice tailored to your unique situation. Always consult with your doctor or healthcare professional before making any decisions about antidepressant medications.

Understanding different types of antidepressants

Selective Serotonin Reuptake Inhibitors (SSRIs): SSRIs are a common type of antidepressant that work by increasing the levels of the neurotransmitter serotonin in the brain. Some well-known SSRIs include Prozac (fluoxetine), Zoloft (sertraline), and Lexapro (escitalopram). SSRIs are generally considered first-line treatments due to their effectiveness and tolerability.
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): SNRIs, such as Effexor (venlafaxine) and Cymbalta (duloxetine), increase the levels of not only serotonin but also norepinephrine, another neurotransmitter. SNRIs may be suitable if SSRIs do not provide sufficient relief from depressive symptoms.
Atypical Antidepressants: This category includes a variety of medications that do not fit into other classifications. Wellbutrin (bupropion) and Remeron (mirtazapine) are common examples. These medications work by modulating the levels of various neurotransmitters in the brain, including serotonin, norepinephrine, and dopamine. They can be used in addition to other medications such as SSRIs or SNRIs, or as alternatives when other options have not been effective or have caused side effects.
Tricyclic Antidepressants (TCAs): TCAs such as Elavil (amitriptyline) and Anafranil (clomipramine) were among the earliest antidepressants. While effective, they may come with a greater risk of side effects and are usually considered after other options have been explored.
Monoamine Oxidase Inhibitors (MAOIs): MAOIs such as Nardil (phenelzine) and Parnate (tranylcypromine) can be effective but carry greater risk of side effects. They also require certain dietary restrictions and can interact with other medications. For these reasons, MAOIs are typically only considered if other options have not been effective.

Factors to consider

When discussing antidepressants with your provider, consider the following factors:

Symptoms and Diagnoses: Your specific symptoms, the type of depression you are experiencing, and any other mental health conditions you have can all influence the choice of antidepressant. Some antidepressants can be helpful in treating other mental health conditions such as anxiety disorders, whereas other antidepressants may carry a risk of exacerbating these conditions.
Medical History: Inform your doctor about your medical history, including any existing conditions and medications you are taking, to avoid interactions and side effects.
Side Effects: Different antidepressants can have varying side effects. Discuss these potential effects with your doctor to find an option that aligns with your preferences.
Response to Previous Treatments: If you have tried other treatments before, discuss their effectiveness and any adverse reactions you may have experienced.

Alternatives to antidepressant medication

In addition to traditional antidepressant medications, there are alternative treatments that may be considered under specific circumstances. These treatments can offer viable options for individuals who have not found relief from standard antidepressants or are looking for antidepressant alternatives due to various reasons.

Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive procedure that uses magnetic pulses to stimulate specific areas of the brain associated with mood regulation. TMS is often considered when other treatments such as antidepressant medication have not been effective or have caused intolerable side effects. TMS is typically administered in the clinic over a treatment course of several weeks, with minimal discomfort and no need for anesthesia. Brand names for TMS devices include NeuroStar and BrainsWay.
Spravato (Esketamine) Nasal Spray: Spravato is an FDA-approved nasal spray containing esketamine, a derivative of ketamine. It is used for treatment-resistant depression when standard antidepressants have not provided relief. Spravato is administered under the supervision of a healthcare professional and has the potential to provide rapid relief from depressive symptoms.

Geode currently offers TMS therapy at the following locations:

We are also proud to offer Spravato treatment at the following locations:

We are constantly expanding our offerings to provide more patients with the treatment they need for depression and other mood disorders.

Are alternative treatments right for you?

When considering alternative treatments such as TMS or Spravato, it’s important to discuss the following factors with your healthcare provider:

Treatment History: Your doctor will want to know about your previous treatments and responses to them. This helps determine whether alternative options are suitable for your situation.
Severity of Symptoms: Alternatives like TMS and Spravato are often considered for more severe cases of depression or when standard treatments have not been effective.
Potential Benefits and Risks: Understand the potential benefits and risks associated with alternative treatments. Your doctor can provide you with information to help you make an informed decision.
Medical Considerations: Your medical history, current health status, and any existing conditions are important factors in determining whether you are a suitable candidate for these treatments.
Cost and Insurance: Investigate the cost of alternative treatments and whether they are covered by your insurance plan. These treatments might have different coverage considerations compared to antidepressant medications.

Choosing the right antidepressant is a collaborative process between you and your healthcare provider. This guide serves as an introduction to the different types of antidepressants available, along with key factors to consider during your conversation with your Geode provider. Always remember that an expert mental health practitioner’s guidance is essential in making an informed decision that aligns with your unique needs and circumstances. Book an appointment with a Geode provider near you today to discuss your treatment options.